GX and research partners have published a review on the evidence for primary prevention against waterborne diseases, which are some of the most enduring and economically devastating biological hazards in the world. This is the third review in a series looking at Health Emergency and Disaster Risk Management in low-income countries. This review identified 8 main interventions and their strength of evidence, the enabling factors, barriers, co-benefits, and alternative measures. It was found that there is strong evidence supporting the effectiveness of water treatment and safe household water storage, and interventions were effective when applied together by individuals and households. Multi-sectoral governance is required to mitigate against waterborne diseases, such as building sanitation infrastructure and streamlined waste management. The research identified gaps relating to evidence-based alternative interventions for resource-poor settings, and showed variations in defining interventions across research institutions, creating challenges in the direct comparison of results across studies. This research will lead to potential project improvement and development across GX partner countries.